枢复宁合用氟哌利多预防腹部手术后恶心呕吐的临床观察

Clinical observation of balanced antiemesis in the prevention of nausea and vomiting after ventral operation

目的:观察枢复宁与氟哌利多联合应用预防腹部手术后恶心呕吐的效果。方法:144例择期腹部手术患者随机分为Ⅰ,Ⅱ,Ⅲ,Ⅳ组,分别静脉注射生理盐水5 mL,枢复宁4 m g,氟哌利多1.25 m g,枢复宁4 m g+氟哌利多1.25m g,统计恶心呕吐的发生率。结果:Ⅰ组恶心呕吐发生率明显高于其他3组,差异有显著性(P<0.01),Ⅳ组患者恶心呕吐发生率明显低于Ⅱ组和Ⅲ组,差异有显著性(P<0.01)。结论:枢复宁与氟哌利多单独应用可预防腹部手术后恶心呕吐,联合应用效果优于单独用药。

Objective To observe the efficacy of a combination of ondansetron and droperidol in the prevention of nausea and vomiting after ventral operation. Methods One hundred forty-four patients for ventral operation were randomly into four groups, group Ⅰ receiving 5 mL of Saline, group Ⅱ 4 mg of ondansetron, group Ⅲ 1. 25 mg of droperidol and group Ⅳ 4 mg of ondansetron 1.25 mg of droperidol. Their rates of nausea and vomiting were recorded. Results The rate of nausea and vomiting in group Ⅰ was significantly higher than the other groups （P〈0.01） and the rate of group Ⅳ was significantly lower than group Ⅱ and group Ⅲ （P〈0.01）. Conclusion Ondansetron and droperidol are effective in the prevention of nausea and vomiting after ventral operation but the combination therapy of the two is more effective than either one used alone.