精神分裂症病人乙型肝炎病毒感染的血清流行病学调查

A controlled study of hepatitis B virus infection in schizophrenic patients.

对244例精神分裂症病人与91例一般内科病人和106例正常人作了乙型肝炎病毒(HBV)感染的比较,其中73例精神分裂症病人作了12个月随访。结果表明:精神分裂症病人、内科病人和正常人的HBV累积感染率分别为76.64%、58.24%和53.77%,精神分裂症病人的HBV感染率与内科病人和正常人比较有极显著性差异,而内科病人与正常人比较相差不显著;73例随访精神分裂症病人的HBV感染率随住院时间延长而升高;住院可能是形成精神分裂症病人HBV感染的主要原因之一。

Objective: To study the prevalence and risk factors for hepatitis B virus infection in schizophrenic patients. Method: The prevalence off hepatitis B virus (HBV) inflection in 244 schizophrenic patients was compared with that off 91 general medical patients and 106 normal subjects. Of 244 schizophrenic patients, 73 were followed up for over 12 months. Results: The prevalence of HBV markers (previous and current inflection) in patients was 76.64%. This was significantly higher than that of general medical patients and normal subjects, which were 58.24% and 53.77% respectively. In 73 schizophrenic patients who were followed up, the prevalence of inflection in creased with the duration of hospitalization. Discussion: Hospitalization was likely to be the main cause of HBV infection in schizophrenic patients. The following measures may decrease the risk of HBV infection: (1)good hygienic habit; (2)strict disinfection of articles for patients^(?) daily use; (3)therapy for enhancing liver function during antipsychotie drugs treatment.