异体骨的临床应用

STUDY ON THE APPLICATION OF ALLOGENEIC BONE TRANSPLANTATION

目的了解异体骨移植相关临床应用的现状和趋势。方法广泛回顾近5年国内外异体骨移植的临床应用。结果异体骨可加工成小块骨、大段骨、颗粒骨及骨环等生物特性各异的移植材料,广泛应用于骨缺损填充、假体翻修、肿瘤切除保肢和关节融合等领域,并获得良好效果;但大块异体骨结构性移植带来的各种并发症不容忽视。结论异体骨移植的主要优点是能够与宿主骨整合并塑形,可替代自体骨移植,实现骨结构和功能重建。如何加速整合、塑形及减少并发症将是其临床应用急需解决的重要课题。

Objective To explore the clinical application of allogeneic bone transplantation. Methods Related literatures on clinical application of various aIIograft Results The aIIografts could be processed into various bone materials of the past 5 years were extensively reviewed kinds of transplanting materials, such as small blocks, large segments, morselised or granular material, and bone ring, so that they could be applied to bone defect filling, prosthesis revision, limb preservation after tumor resection, and joint fusion. All these applic results. However, complications resulted in the structural Conclusion The reconstruct bone advantage of bone allograft of large ations ended up with good clinical block bones could be overlooked. integrated with host bone and be remodelled, so as to structure and function. How to accelerate their integration and remodelling while exerting normal functions is the problem that requires solution