正常青年人英汉认知活动与脑血流速度变化的关系

Association between different cognitive activities and cerebral blood flow velocity changes in normal young people

目的:探讨不同的中英文语言认知活动对脑血流速度的影响及性别对脑血流速度变化的影响.方法:在完成不同的语言认知任务时及其先前的休息期,对45位正常志愿者(右利手)用经颅超声多普勒监测其双侧大脑中动脉血流速度的变化.结果:完成不同的认知任务时与休息时期相比,所有认知任务的完成均发现双侧大脑中动脉血流速度显著增加,汉语词语联想脑血流速度相对增加,左侧为14.2±4.7,右侧为8.5±2.8;英语词语联想相对增加,左侧为13.5±2.9右侧为8.0±2.3;汉语句子重建相对增加,左侧为13.8±3.2,右侧为8.6±2.2;英语句子重建相对增加,左侧为11.9±4.0,右侧为7.7±2.8;汉语同义词相对增加,左侧为13.0±6.4,右侧为7.3±3.1;英语同义词相对增加,左侧为9.8±4.3,右侧为7.7±3.1;并显现出显著的左侧半球偏侧化.性别对部分认知活动诱导的脑血流速度变化产生影响.结论:中英文语言认知活动均可引出脑血流的左侧偏侧化增加.

AIM： To investigate the changes of cerebral blood flow velocity （CBFV） induced by a variety of cognitive tasks and to determine the influence of gender and language-related cognitive tasks such as Chinese and English on the relative CBFV changes. METHODS： Simultaneous bilateral TCD monitoring of CBFV in the middle cerebral arteries （ MCAs ） was performed in 45 right-handed normal volunteers during 6 verbal tasks and their preceding rest periods. RESULTS： The relative CBFV changes of Chinese word generation were 14.2 ±4.7 in left and 8.5 ± 2.8 in right and those for English word generation were 13.5 ± 2.9 in left and 8.0 ± 2.3 in right. For Chinese sentence reconstruction, the relative CBFV changes were 13.8 ±3.2 in left and 8.6 ±2.2 in right and for English sentence reconstruction they were 11.9 ± 4.0 in left and 7.7 ± 2.8 in right. For Chinese synonyms, the changes were 13.0 ±6.4 in left and 7.3 ±3.1 in right while for English synonyms they were 9.8 ± 4.3 in left and 7.7 ± 3.1 in right respectively. All cognitive tasks induced a significant bilateral CBFV increase in the MCAs and showed a significant left-hemisphere CBFV acceleration. Gender showed higher relative CBFV changes when some tasks were performed. CONCLUSION： Chinese and English cognitive tasks can induce a significant lateralized left-hemispheric CBFV acceleration.