胃癌癌前病变的中医分型与CDK_4、PCNA和Ki-67蛋白表达的关系

The Relativity on the Syndrome of Precancerous Lesions of Gastric Cancer and the Protein Expression of CDK_(4), PCNA and Ki-67

目的探讨胃癌癌前病变(PLGC)中医分型与CDK4、PCNA和Ki-67蛋白表达的相关性。为本病中医证型的客观化开辟一条新途径。方法采用免疫组化法检测51例PLGC患者的CDK4、PCNA和Ki-67蛋白的表达情况,并与中医辨证分型相比较。结果CDK4在气滞、胃热、血瘀各型当中均有较明显的表达,各型之间相比无显著性差异(P>0.05)。气滞型的PCNA、Ki-67的蛋白表达明显高于血瘀型(P<0.05)。结论胃黏膜良性病变的加重与中医分型的演变规律存在一定的关系。

Objective To investigate the relativity on the TCM syndrome of PLGC and the protein expression of CDK4, PCNA and Ki-67. Methods The expression of CDK4, PCNA and Ki-67 of 51 PLGC cases are detected by immunohistochemistry and compared with the syndrome of TCM. Result All the CDK4 expression of Qi stagnation syndrome, stomach-heat syndrome and blood stasis are evident （P〉0.05）. The PCNA and Ki-67 expression of blood stasis syndrome is more evident than of Qi stagnation （P〈0.05）. Conclusion The seriouslity of benign pathological changes of gastric mucosa are related to change law of TCM syndrome to some extent.