肾阳虚与血瘀关系的实验研究

Experimental Study of the Correlation of Deficiency of Kidney-Yang and Stagnation of Blood

目的探讨肾虚与血瘀之间的发展变化规律,为补肾活血法提供实验依据。方法制作肾阳虚动物模型,选取Wistar大鼠37只,分为对照组、模型组、治疗组。观察动物外观、一般体征、脏器重量和血脂等改变。结果模型组动物皮毛稀疏,精神萎靡,懒动,大便溏稀,耳垂毛细血管紫暗;模型组肾上腺、精囊腺的重量与对照组比较明显降低;血清睾酮含量降低;模型组血清TC和LDL-C明显增高,TG增高不明显,HDL-C降低。结论肾阳虚同时伴有血瘀,血瘀时间的延迟可出现肾阳虚。

Objective To study the change law between deficiency of kidney-Yang and stagnation of blood, and supply a study evidence for the therapy method of invigorate the kidney and promoting blood flow. Method 37 Wistar rats which were made of the model of deficiency of kidney-Yang, were randomly divided into three groups： control group, model group and treatment group. Changes including appearance, general objective sign, organ weight, microcirculation and blood rheology were recorded. Result Phenomenons, including rare fur, depression, lazy, duck stools and purpl dim in micrangium micrangium, occurred in model group. The weight of adrenal body and seminal vesicle and the contents of serum andrusol in model group were lower than those in control group. And in model group, significant increasing TC and LDL-C and decreasing HCL-C were observed. Conclusion Deficiency of kidney-Yang is associated with stagnation of blood, and the time delay of stagnation of blood can lead deficiency of kidney-Yang.