野生雪莲和培养雪莲总黄酮主要药效作用比较研究

The Comparative Study on Main Medical Effect of Total Flavone in Culture of Saussurea Medusa Maxim and the Wild One

目的观察野生、培养雪莲总黄酮的镇痛、抗炎以及免疫调节作用。方法采用小鼠热刺激甩尾实验、小鼠耳肿胀法、大鼠角叉菜胶性足跖肿胀实验以及小鼠脾脏T、B淋巴细胞转化实验观察野生、培养雪莲总黄酮的镇痛、抗炎以及免疫调节作用。结果野生、培养雪莲总黄酮对热刺激所致疼痛具有明显的镇痛效果;对小鼠耳肿胀和大鼠足肿胀有明显的抑制作用;对小鼠T、B淋巴细胞转化功能都有明显抑制作用;野生与培养雪莲总黄酮的主要药效作用无显著性差异。结论野生、培养雪莲总黄酮都具有镇痛、抗炎以及免疫抑制作用,二者作用无显著性差异。

Objective To study anti-inflammatory, analgesic and immunomodulatory effect of total flavone in culture of Saussurea medusa Maxim and the wild one. Methods Different pain, inflammatory and immune models were made to investigate the anti-inflammatory, analgesic and immunomodulatory effect of total flavone in culture of Saussurea medusa Maxim and the wild one such as paw edema in mice, ear edema in rats and so on. Results There are obvious analgesic effect in pain caused by heat in total flavone in culture of Saussurea medusa Maxim and the wild one, and they have obvious restraining effect on paw edema in mice and ear edema in rats as well as on the function of transformation of lymphocyte T and B in rats. Moreover, there is no obvious difference between total flavone in culture of Saussurea medusa Maxim and the total flavone of the wild one. Conclusion Total flavone in culture of Saussurea medusa Maxim and the wild one possess anti-inflammatory, analgesic and immunomodulatory effect, and there is no obvious difference between them.