广谱驱虫药阿苯达唑合成工艺的改进

Improved Synthesis of Albendazole

通过改进广谱驱虫药阿苯达唑的合成工艺,提高产品质量和收率,降低生产成本,简化操作.以价廉易得的农药多菌灵为原料,经氯磺化、铁粉还原、碱催化条件下硫醚化合成了阿苯达唑,并对氯磺化、还原和硫醚化工艺进行改进.产品总收率由文献报道的50.7%提高到60.4%,新工艺反应步骤简便、生产成本低,易于进行工业化生产.

To improve the synthetic technology, albendazole is synthesized from carbendazole by sulfochlorination, reduction of iron powder and thiolation under alkalinious catalyst condition. The sulfochlorition, reduction and thiolation are improved. The overall yield of Albendazole has been heightened from 50.8% to 60.4%. This new technology has the advantages of simple process, lower cost and higher yield, which is fit to industrialize.