针刺四缝穴治疗小儿疳证多中心随机对照研究

Multicentral randomized controlled study on acupuncture at Sifeng (EX-UE 10) for treatment of infantile malnutrition

目的:评价针刺四缝穴治疗小儿疳证的疗效。方法:采用多中心、随机、对照、单盲临床试验,将222例患儿分为针刺组(110例)和药物组(112例)。针刺组采用针刺双手四缝穴,每周1次,共4次;药物组口服益气健脾口服液,每日2次,每次1支,共4周。疗效评价包括症候积分量表中症状改善程度及血清胰岛素样生长因子Ⅰ(IGFⅠ)、前白蛋白(PA)、血红蛋白和红细胞计数的变化。结果:4个中心共纳入222例病例,212例完成试验。针刺组在改善患儿的食欲、体重、腹部皮下脂肪厚度等方面优于药物组(P<0.01),在改善身高方面两组无差异。两组在提高血清IGFⅠ水平上无统计学意义,在提高PA水平上针刺组优于药物组(P<0.05)。两组在提高血红蛋白和红细胞计数方面,针刺组治疗前后差异均有非常显著性意义(P<0.01),药物组的红细胞计数在治疗前后无统计学意义。结论:针刺四缝穴治疗小儿疳证疗效显著,值得临床广泛推广应用。

Objective To evaluate therapeutic effect of acupuncture at Sifeng （EX-UE 10） on infantile malnutrition. Methods Multicentral, randomized, controlled and single blind test was adopted. 222 infants of malnutrition were divided into an acupuncture group （ n = 110） and a medicine group （ n = 112）. The acupuncture group were treated with acupuncture at bilateral Sifeng （EX-UE 107, once each week, for 4 times; and the medicine group were treated with oral administration of Yiqi Jianpi Oral Liquid, twice each day, one ample each time, for 4 weeks, The therapeutic effect was evaluated by improvement of symptoms and signs in the syndrome cumulative score scale, and changes of serum insulln-like growth factor- Ⅰ （IGF- Ⅰ ）, pre-albumin （PA）, hemoglobin and red-cell count. Results Two hundred and twenty-two cases were enrolled in the 4 centers and 212 cases completed the test. The acupuncture group in improvement of appetite, body weight, subcutaneous fat thickness of the abdomen, etc. were superior to the medicine group （P〈0.01）, hut there was no significant difference between the two groups in improvement of the body height. There was no significant increase of serum IGF- Ⅰ level in the two groups, and the acupuncture group in increase of PA was superior to the medicine group （P〈0. 05）. After treatment, hemoglobin and red-cell count increased significantly in the treatment group （P〈0. 01）, and hemoglobin increased significantly in the medicine group. Conclusion Acupuncture at Sifeng （EX-UE10） has obvious therapeutic effect on infantile malnutrition.