丙氨酸氨基转移酶及总胆红质正常的慢性肝炎病毒携带者肝组织病理的分级和分期研究

Pathological grades and stages in chronic hepatitis B virus carriers

目的探讨肝功能正常的慢性肝炎病毒携带者的肝组织病理分级和分期。方法收集我院门诊体检肝功能检查丙氨酸氨基转移酶(ALT)及总胆红质(TBiL)正常的287例慢性病毒携带者肝穿病理标本,常规HE染色,光镜下观察其病理变化,并进行分级和分期。结果总异常率为90.94%。光镜下肝组织正常26例,分级为G1者占59.93%,明显高与其它各组(P<0.01)。结论肝功能正常的慢性病毒携带者约91%肝组织存在炎性改变,但纤维化程度较轻,约9%的患者肝组织基本正常。

Objective To study liver pathology in chronic hepatitis B virus （HBV） carriers with normal liver function. Methods Two hundred and eighty-seven of liver biopsy specimens from ehronic HBV carriers with normal ALT and TBiL were investigated. All specimens were observed under the light telescope after HE staining and categorized as grades and stages. Results Inflammatory reaction was discovered in 90.94% specimens. Grade 1 （59.93%） was far more than others（P 〈 0. 01 ）. Conclusion Inflammation changes are existed in 91 percent of pathological specimens in chronic HBV carriers with normal liver function,but fibrosis is mild.