急性冠脉综合征患者血清sFas水平变化分析

Elementary research for the variation of levels of serum soluble Fas in patients with acute coronary syndrome

目的:探讨血清可溶性Fas(solub le Fas,sFas)水平与急性冠脉综合征(acute coronary syndrom e,ACS)的关系。方法:采用酶联免疫吸附双抗体夹心ABC-ELISA方法,测定22例急性冠脉综合征患者(ACS组)和10例对照组受试者血清sFas的水平,其中ACS组中21例同时应用该方法进行血清肌钙蛋白I(cTnI)定量检测。结果:ACS组患者血清sFas水平均明显高于对照组(P<0.01);ACS患者中cTnI升高组(M I)与正常组(UA)血清sFas水平差异无显著性(P>0.05)。结论:高水平的血清sFas与急性冠脉综合征有关,可能在易损斑块的破溃过程中扮演重要角色。

Objective ： To explore the relationship between level of serum soluble Fas（sFas） and acute coronary syndrome（ACS）. Methods ：The level of sFas was measured in the sera from 22 patients with ACS and 10 controls by enzyme-linked immunosorbent assay （ ELISA）. The cardiac tropnin I （cTnI） of 21 ACS patients were measured at the same time. Results：The mean level of serum sFas was significantly higher in the patients with ACS than that of the controls （ P 〈 0.01 ）. No difference was found between the groups with increased（MI） cTnI and normal（UA） cTnl in patients with ACS（ P 〉 0.05）. Conclusions：High level of serum sFas is related to ACS, which may play an important role in the rupture of vulnerable atheromatous plaque.