舒必利治疗妄想性抑郁症临床观察

Sulpiride in the treatment of delusional depression.

对80例妄想性抑郁症以舒必利治疗与奋乃静合并阿米替林治疗的效果及副反应进行对照观察。结果表明这两种治疗的效果及副反应基本相同,但舒必利见效较快。

Objective: To study the effect of sulpiride on delusional depression. Method: Eighty patients with delusional depression received sulpiride and were compared with those who took both trilafon and amitriptyline. Results: The therapeutic and side effects of these two groups of drugs were similar, but sulpiride had a quicker onset of action. Discussion: The results supported Kairach's finding that sulpiride was effective in delusional depression, though the therapeutic mechanism was unclear. Kaskeg et al suggested that there were abnormalities in both the dopamine and norepinephrine neuro-transmitter systems in patients with delusional depression. As a selective inhibitor of DA receptors, sulpiride may stimulate D2 and possibly D1 receptors, and this may account for its antipsychotic effect. The authors recommended that sulpiride was more suitable for elderly and physically weak patients. However, double-blind controlled studies are needed to further address this issue.