83例晚发性和早发性躁狂症对照研究

A controlled study of 83 patients with late—onset versus early—onset mania.

回顾性研究了38例晚发性躁狂症和45例早发性躁狂症病人的临床特点。结果显示:与早发躁狂症相比,晚发躁狂症病人敌意破坏、假性痴呆、荒谬妄想、记忆障碍较多,而情感高涨、性兴趣及阳性家族史明显较少;病前多有社会心理因素及躯体疾病;药物副反应明显。

Objective: To compare the clinical characteristics of late—versus early—onset mania. Method: This was a retrospective study of the clinical characteristics of 38 patients with late—onset mania and 45 patients with early—onset mania. Results: Compared to early—onset mania, there were more hostility, assaultiveness, pseudo—dementia, delusion with incredible content and memory deficit in late—onset mania, where elation, sexual drive, family history were less common, and psychosocial factors, pre—existing physical diseases, and side effects of drugs were more frequently found. Discussion: The clinical characteristics of patients with late—onset mania suggested a higher possibility of organic lesions in the brain. Stone reported that among 92 senile patients with mania, there were organic cerebral lesions in 22 patients, while 14 patients had memory deficits. Although the therapeutic effect of lithium in senile patients was also good, their lower renal clearance means that a lower dosage is sufficient, and that greater care should be exercised during treatment.