血浆谷胱甘肽S-转移酶P与消化道肿瘤的关系

Measurement of acidic glutathione S-transferase in patients with gastrointestinal malignancies

目的探讨血清谷胱甘肽S-转移酶与消化道肿瘤的关系,筛选肿瘤检测的血清标志物。方法采用放免法测定消化道肿瘤患者(胃癌16例,食管癌4例,肝癌8例,结肠癌8例)血浆谷胱甘肽S-转移酶(GST-p)的含量和活性改变。结果 GST-p在胃癌、食管癌、肝癌及肠癌等病时升高(27.5±24.5μg/L),明显高于正常人组(7.1±2.3μg/L);GST-p在癌前病变组高于正常人组(P<0.01);GST-p含量与肿瘤的分化程度呈正相关。结论 GST-p不仅是机体损伤解毒的酶,它与肿瘤的发生、发展有关,是肿瘤早期诊断有价值的标志酶。

AIMS To study the relation between plasma acidic glutathione S-trans-ferase (GST-p) and gastrointestinal malignancies and screen plasma tumor markers in tumor patients. METHODS Radioimmunoassay (RIA) was used for the measurement of human acidic glutathione S-transferance (GST-p) in plasma of gastrointestinal malignancies (gastric cancer, 16 patients; esophageal cancer, 4; liver cancer, 8 and colon cancer, 8). RESULTS The mean values of plasma GST-p in 25 normal individuals, 6 patients with precancerous lesions, 36 patients with gastrointestinal malignancies were 7.1±2.3, 24.3±20. 9 and 27.5±24.5 μg/L respectively. There was a significant elevation in tumor patients than that in begnin disease and control groups(P<0.01). CONCLUSIONS GST-p may be a useful marker for early diagnosis of gastrointestional malignancies clinically, and may play a significant role in the process of carcinogenesis and development of tumor.