摘要
目的探讨幽门螺杆菌(Hp)感染、血清胃液素与胃癌发病的关系。方法对经内镜和病理检查证实的胃癌65例,取胃窦部粘膜组织1块,空腹静脉血测定Hp(1min尿素酶试验)和血清胃液素(放射免疫法)。另以30例Hp阴性慢性浅表性胃炎作为对照组。结果胃癌65例中20例Hp阳性(30.8%),血清胃液素均值83.05±23.95 ng/L,45例Hp阴性胃癌血清胃液素92.93±38.10 ng/L(P>0.05),其中12例胃体部癌和53例胃窦部癌血清胃液素为81.16±36.31 ng/L和91.69±30.65 ng/L(P>0.05)。30例慢性浅表性胃炎血清胃液素值122.16±39.74 ng/L明显高于胃癌组(P<0.01)。结论 Hp感染、血清胃液素水平与胃癌发生无明确关系。
AIMS To evaluate the relationship of Helicobacter pylori (Hp) infection, serum gastrin level and the pathogenesis of gastric cancer. METHODS The gastric antrum mucosal tissue and venous blood from 65 patients with gastric cancer confirmed by endoscopy and pathology was examined for Hp using one minute urease test and for serum gastrin with RIA respectively. In addition 30 cases of chronic superficial gastritis proved negative for Hp served as controls. RESULTS Among 65 patients with gastric cancer, 20 patients were proved positive for Hp(30.8%). The mean value of serum gastrin was 83.05±23.95 ng/L. Other 45 patients with gastric cancer were proved negative for Hp and the mean value of serum gastrin was 92.93±38. 10 ng/L(P>0.05). The mean value of serum gastrin in patients with chronic superficial gastritis was 122.16±39.70 ng/L. There was a significant difference between the gastric cancer group and the chronic superficial gastritis group (P<0.01). CONCLUSIONS Although these data do not prove a relationship between the Hp infection, serum gastrin level and the histogenesis of gastric cancer, but it should he further investigation.
