摘要
目的为解决治疗前后采样部位差异问题,用胃粘膜内注墨法标记了胃癌前病变,追踪观察叶酸的疗效。方法胃粘膜异型增生患者75例,在病灶周围粘膜内注入印度墨水。分为叶酸治疗组和一般胃病治疗药对照组,在标记病灶范围内活检随访检查。结果注墨后胃粘膜内呈现清晰可见的小黑点,存留时间18±9(14-29)月,无不良反应。叶酸组疗效为41.0%(18/39),对照疗效为38.9%(14/36),二者比较,P>0.05。结论本方法标记胃癌前病变易行、可靠、安全。叶酸治疗胃癌前病变效果与一般胃病治疗药无显著差异。
AIMS To facilitate the relocation of biopsy sites in follow-up endoscopic examination for precancerous leisons treated with folic acid. METHODS India ink was injected by endoscopy in 75 patients with gastric dysplasia. They were divided into folic acid group and control group. Endoscopic and pathologic examination were followedup for 1-3 years. RESULTS Intramucosal injection sterile India ink produced a zone of black coloration that was grossly visible and presserved 18±9(14-29) months. Improvement in mucosal dysplasia were 41.0(18/39) in folic acid and 38.9(14/36) in control group. CONCLUSIONS The gastric tattooing can easily and sfely marked the lesion with dysplasia, by which the therapeutic efficacy of folic acid on gastric dysplasia is considered no difference from control group.
基金
安徽省医学重点科研课题
NO.91008
关键词
胃肿瘤
癌前状态
叶酸
folic acid precancerous conditions
