麝香草的新单萜配糖物的分离与合成

Synthesis and Isolation of a New Monoterpene Glucoside from Thyme

从麝香草(ThymusvulgarisL)的甲醇萃取物中分离出三个单萜配糖物.用核磁共振光谱确定了它们的结构为对伞花-9-基-β-D-葡糖苷(1),5-β-D-葡糖苷百里氢醌(2)和2-β-D-葡糖苷百里氢醌(3).其中1是新化合物,用以对伞花-9-醇为原料的对映体选择性合成方法确定了化合物1的8位的立体化学为R型.

Three monoterpene glucosides were isolated from the methanol extract of thyme （Thymus vulgaris L.）. They were identified as p-cymen-9-ββ-D-glucopyranoside （1）, 5-β-D-glucopyranosylthymoquinol （2） and 2-β-D-glucopyranosylthymoquinol （3） by spectral evidence. 1 is a new compound, but 2 and 3 are known compounds. The stereochemistry at C-8 of 1 was elucidated to be R-form by enantioselective synthesis from p-cymen-9-ol.