内皮祖细胞与动脉粥样硬化蚀损斑块合并血栓形成

Relationship Between Endothelial Progenitor Cells and Atherosclerotic Plaque Erosion and Thrombosis

动脉粥样硬化易损斑块是急性冠脉综合征和心脏缺血性猝死的重要病理基础。蚀损斑块是易损斑块的重要病理类型之一,其主要特点:斑块表面大面积内皮细胞脱落和血栓形成。目前有关蚀损斑块合并血栓形成机制的研究罕见。近年的研究认为,内皮祖细胞参与血管内皮损伤后的修复。因此,内皮祖细胞可能参与蚀损斑块合并血栓形成,或对其有治疗作用,此方面研究国内外未见,值得探讨。

Atherosclerotic vulnerable plaque is considered as an important pathologic basis of acute coronary syndrome and sudden cardiac ischemic death. Eroded plaque,which is characterized with endothelial denudation and thrombosis,is a type of vulnerable plaque. The mechanisms of eroded plaque are poorly understood. Recent researches demonstrated that endothelial progenitor cells play an important role in repair of injured endothelium. So the relationship between endothelial progenitor cells and eroded plaque and thrombosis is worth investigating.