内皮微粒与心血管疾病

Endothelial Microparticles and Cardiovascular Disease

内皮微粒(EMP)是内皮细胞在激活或凋亡状态下所释放的微小囊泡状物质,由脂质双分子层膜和膜内容物组成。在多种疾病状态下均有EMP含量升高的表现。在心血管疾病(CAD)的发生过程中,EMP通过启动外源性凝血途径以及与血小板形成聚合物可促进血栓和纤维蛋白的形成;激活中性粒细胞,促进单核细胞与内皮细胞结合并对中性粒细胞产生趋化作用,参与炎症反应的发生;影响血管内皮功能,削弱Ach介导的血管舒张反应,这些都对CAD的发生均起了重要作用。通过体内EMP水平的测定可以对CAD进行诊断,并对冠脉病变程度作出评估,也可以监测CAD的治疗效果,可以作为诊断心血管疾病的新方法。

Endothelial microparticles（EMP） are small vesicles released from endothelial cells （EC） during their activation or apoptosis,and it＇s composed of a phosphblipid bilayer membrane and the intravesicular contents. Many disease status has an elevated EMP level. In the pathogenesis of cardiovascular disease （CAD） , EMP can initiates coagulation through the extrinsic coagulation pathway ,form a polymeride with the platelet,thus can promote the generation of thrombus and fibrin ; activate neutrophil, promote monocyte-endothelial cell binding and chemotactic attract leukocytes, participate the inflammatory reaction ; cause endothelial dysfunction, impair the endothelium-dependent relaxa- tion induced by Ach. These all make great contribution to the pathogenesis of CAD. We can diagnosis CAD though the measurement of in vivo EMP,assess the extend of the cardiovascular injury and monitor the treatment so that it can be a new method to diagnosis CAD.