摘要
动脉粥样硬化(atherosc lerosis,AS)目前被广泛认为是一种慢性炎症性疾病,炎症反应与斑块的不稳定性密切相关。CD163作为血红蛋白特异清道夫受体,近年被研究发现可以调节血红素氧合酶-1(hem e oxygenase-1,HO-1)的表达,而后者已经大量实验证明具有抗炎、抗氧化作用。因此有学者提出,CD163/HO-1通路作为一个新的抗炎途径,有望在稳定动脉粥样硬化不稳定斑块中起着重要作用。
Atheroslerosis is generally accepted as a chronic inflammatory disease, Inflammation is associated with vulnerable plaque evolution. CD163,as a hemoglobin scavenger receptor.can regulate the expression of heme oxygenase-1 which has been demonstrated to have an important role in anti-inflammation and anti-oxidation, So,some scholar propose that CD163/HO-1 pathway is hopeful to play a critical role in atherosclerotic vulnerable plaque stabilization,
出处
《心血管病学进展》
CAS
2006年第1期57-59,共3页
Advances in Cardiovascular Diseases
