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过氧化物酶体增殖物激活受体与心肌缺血再灌注损伤 被引量：3

Peroxisome Proliferator-activated Receptors and Ischemic Reperfusion Injury
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摘要 过氧化物酶体增殖物激活受体作为核受体超家族的一员,其作用广泛,它涉及脂质和脂蛋白代谢,葡萄糖代谢,细胞增值分裂和凋亡。其中,过氧化物酶体增殖物激活受体与心肌缺血再灌注损伤中也起着重要的作用,现就此作一综述。 Peroxisome proliferator-activated receptors{ PPARs） are nuclear receptors that function as regulators of lipid and lipoprotein metabolism and glucose homeostasis and influence cellular proliferation, differentiation and apoptosis. There are many studies to estimate PPARs playing a role in isehemic reperfusion injury.
作者 王显红 陈明
机构地区 重庆市第九人民医院心内科 重庆医科大学附属第一医院心内科
出处 《心血管病学进展》 CAS 2006年第1期97-99,共3页 Advances in Cardiovascular Diseases
关键词 过氧化物酶体增殖物激活受体 缺血再灌注损伤 peroxisome proliferator-activated receptors ischemic reperfusion injury
分类号 R541 [医药卫生—心血管疾病]
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参考文献15

  • 1Issemann I, Green S. Activation on a member of the steroid receptor superfamily by peroxisome proliferators[J]. Nature, 1990,347 : 645 -650.
  • 2Fruchart JC, Duriez P, Staels B, et al. Peroxisome proliferator-activated receptoralpha activators regulate genes governing lipoprotein metabolism,vascular inflammation and atherosclerosis [J]. Curt Opin Lipidol, 1999,10:245-257.
  • 3Inoue I, Goto S, Matsunaga T, et al. The ligands/activators for peroxisorae proliferator-activated receptor alpha( PPARαlpha) and PPARgamma increase Cu^2+ ,Zn^2+ -superoxide dismutase and decrease p22phox message expressions in primary endothelial cells[J]. Metabolism ,2001,50:311.
  • 4Cuzzocrea S, Pisano B,Dugo L, et al. Rosiglitazone and 15-deoxy-12,14-prosta-glandin J2, ligands of the peroxisome proliferator-activated receptor-γ(PPARγ),reduce ischaemia/reperfusion injury of the gut [J]. Br J Pharmacol,2003,140:366-376.
  • 5Beltowski J,Wojcicka G, Mydlarczyk M et al. The effect of proliferator-activated receptorsα(PPARα) agonist, fenofibrate, on lipid peroxidation, total antioxidant capacity,and plasma papaoxonasel( PON1 ) activity[J]. J Physiol Pharmacol,2002,53 ( 3 ) :463-475.
  • 6Tabemero A,Schoonjans K ,Jesel L,et al. Activation of the peroxisome proliferator-activated receptor ct protects against myocardial ischaemic injury and improves endothelial vasodilatation [J]. BMC Pharmacol,2002,2(1):10.
  • 7Delerive P, Fruchart JC, Staels B, et al. Peroxisome proliferators-activated receptors in inflammation control[J]. J Endocrinol,2001,169 :453-459.
  • 8Marx N, Sukhova GK, Collins T, et al. PPARα activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells[J]. Circulation, 1999,99:3125-3131.
  • 9Sun B, Fan H, Honda T,et al. Activation of NF kappa B and expression of ICAM-1 in ischemic-reperfused canine myocardium[J]. J Mol Cell Cardiol,2001,33( 1 ) :109-1119.
  • 10Yue TL, Bao W K, Jucker BM, et al. Activation of peroxisome proliferator-activated receptor-[alpha] protects the heart from ischemia/reperfusion injury[J].Girculation ,2003,108 ( 19 ) :2393-2399.

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心血管病学进展
2006年 第1期

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