男性泌尿生殖道支原体感染与耐药性变迁

Male urogenital mycoplasma and drug resistance evolution

目的:观察本地区男性泌尿道支原体感染率分布情况及药敏变化,为临床用药提供依据。方法:使用MycoplasmaIST2试剂盒对982例疑似支原体感染患者进行解脲脲原体和人型支原体的检测,并做体外药物敏感性分析。结果:测出支原体261例,其中Uu阳性208例,阳性率79.7%;Mh阳性14例,阳性率5.4%;Uu+Mh阳性39例,阳性率14.9%。药敏结果显示不同型别支原体对一些抗生素敏感性具有显著差别。2002-2005年总体药敏趋势表明原始霉素(敏感率97.3%)、交沙霉素(敏感率94.6%)敏感性较高且较稳定,强力霉素(敏感率88.9%)其次,敏感率最低的抗生素为环丙沙星和氧氟沙星,四环素和红霉素敏感呈增强趋势。结论:加强支原体药敏检测,合理选用敏感抗生素,进行规范治疗。无条件进行药敏检测情况下,治疗本地区男性支原体感染宜首选交沙霉素。

Objective To investigate urogenital mycoplasma infection and drug sensitivity in Beijing from July 2002 to June 2005 . Methods Drug sensitivity of 982 urogenital samples to nine antibiotics was detected with Mycoplasma Reagent Box. Results The positive rate of mycoplasma was found as 26.6% （261/982） . In 261 cases, in 261 cases, positive ureaplasma urealyticum （Uu） were 208 cases （79.7%）, which was higher than complicated Uu and Mh infection （39cases, 14. 9% ） or Mycoplasma hominis（Mh） infection （14cases, 5.4% ） . The result of drug sensitivity test showed that Uu Mh and Uu ＋ Mh had different drug resistance. The most sensitive and stable antibiotics were pristinamycin, josamycin and doxycyline, and its rate of sensitivity were 97.3%, 94. 6% and 88.9%, respectively. The lowest rate of sensitivity was ofloxacin and ciprofloxacin. The sensitivity seems to have the trend of increasing for tetracycline and erythromycin. Conclusions It is important to enhance the detection of drug resistance of mycoplasma, guide the use of drugs and prevent from producing antibiotic resistance. Josamycin can be used as the first choice.