儿童髓母细胞瘤的生物学特性研究

BIOLOGICAL CHARACTERISTICS OF MEDULLOBLASTOMA IN CHILDREN

目的探讨儿童髓母细胞瘤的生物学特性。方法采用组织病理学和免疫组化法对84例获随访的儿童髓母细胞瘤组织形态特征标志物表达以及P53、VEGF、PCNA指数等进行比较研究。按术后生存期3年、5年、10年分为A、B、C3组。结果在66.7%的病人中免疫组化标记可共同表达Syn和GFAP。3组间P53表达无显著性差异(P>0.05),而3组之间的VEGF和PCNA均有显著性差异(P<0.01)。结论儿童髓母细胞瘤为原始神经外胚层肿瘤,P53表达与其预后无关,但VEGF和PCNA可作为反映儿童髓母细胞瘤预后的生物学行为指标。

Objective： To investigate the biological characteaistics of medulloblastoma in children. Methods： 84 cases of medulloblastoma in children were observed with histologic and immunohistochemical techniques. Results： In 66.7% of the patients Syn and GFAP were coexpressed. It was found that the correlation between P^53 expression and survival rate was not significant （P 〉 0.05）, but VEGF and PCNA were highly related to survival rate （P 〈 0.001）. Conclusion： The medulloblastoma can be classified as a primitive neuro - ectodermal tumor （PNET）. VEGF expression and PCNA can be the predictors for the biological behavior of medulloblastoma.