具有一般反应的自适应临床设计的渐近推断(英文)

Asymptotic Inference for Response-Adaptive Clinical Trial Design with General Outcomes

研究了具有连续反应的临床试验.首先应用线性秩统计量的渐近理论,获得由Rosenberger提出的无差异治疗效果假设检验统计量的渐近正态性;然后给出一种新的设计且获得相应统计量的渐近正态性.

We consider the clinical trial with a continuous treatment response. First, applying the properties of the linear rank statistic, we obtain the asymptotic normality of the test statistic which is based on rank statistic proposed by Rosenberger and used to test the hypothesis of no treatment effect for a trial with continuous response. Then, we propose another assignment scheme for the trial with continuous response and obtain the asymptotic normality of the corresponding test statistic.