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轻度认知障碍和Alzheimer病的磁共振质子波谱（^1H-MRS）研究 被引量：12

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摘要 随着人口老龄化,伴随记忆力减退老年人越来越受到普遍的关注.轻度认知障碍(mild cognitive impairment,MCI)是介于正常老化和早期痴呆之间的一种过渡状态,反映一种有记忆主诉和客观认知损伤证据但又不能诊断为痴呆的临床状况,MCI患者为老年性痴呆的高危人群,特别是以记忆损害为主的遗忘型MCI常常转化为阿尔茨海默病(Alzheimer,AD),因此加强MCI的临床及基础研究有望对老年痴呆的早期诊断,早期干预有着重要的意义.质子波谱1H-MRS是唯一的检测活体大脑代谢物的诊断性影像学技术.我们对MCI与正常老年人及AD患者的内侧颞叶进行1H-MRS研究,以探讨其对AD早期诊断的重要价值.
作者 江文宇 吕泽平 谢海群
机构地区 广西区江滨医院神经内科
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2005年第6期560-561,共2页 Journal of Apoplexy and Nervous Diseases
基金 广西科学研究与技术开发计划项目(合同编号:桂科攻0472002-22:桂科攻0143061)
关键词 轻度认知障碍 ALZHEIMER病 磁共振质子波谱 老年性痴呆 记忆力减退 阿尔茨海默病 早期诊断 临床状况 人口老龄化 MCI
分类号 R749.16 [医药卫生—神经病学与精神病学] R743.31 [医药卫生—神经病学与精神病学]
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参考文献8

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二级参考文献19

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中风与神经疾病杂志
2005年 第6期

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