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Creutzfeldt-Jakob病1例报告 被引量：1

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摘要 Creutzfeldt-Jakob病(CJD)是可传播的致命性中枢神经系统疾病,以快速进展性痴呆及大脑皮质、基底节和脊髓局灶性病变为特征,是常见的人类朊蛋白病,又称为皮质-纹状体-脊髓变性(corticostriatospinal degeneration)[1].朊蛋白病(朊粒疾病)属于新发传染病范畴,具有一定的传染性,目前已证实CJD与疯牛病密切相关[2].按世界卫生组织要求,中国卫生部与国家疾病控制中心决定,自2003年起我国将有组织有计划地开展对CJD的全面监控.为了提高对该类少见病的警惕,早期诊断,减少漏诊,防止医源性传播,现报道我院近期临床诊断的1例CJD,并结合文献,对其发病机制和临床特点进行分析如下.
作者 陈小转 甘丽
机构地区 安徽省芜湖市中医院神经内科
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2005年第6期564-565,共2页 Journal of Apoplexy and Nervous Diseases
关键词 CREUTZFELDT-JAKOB病 中枢神经系统疾病 世界卫生组织 医源性传播 疾病控制中心 大脑皮质 朊蛋白病 脊髓变性 快速进展性 局灶性病变
分类号 R742 [医药卫生—神经病学与精神病学] R741 [医药卫生—神经病学与精神病学]
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参考文献6

二级参考文献52

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  • 3Bruce ME, McConnell I, Will RG, et al. Detection of variant Creutzfeldt-Jakob disease infectivity in extraneural tissues[J]. Lancet, 2001,358(9277) :208 - 209.
  • 4Kim H, O' Rourke KI, Walter M, et al. Immunohistochemical detection of scrapie prion proteins in clinically normal sheep in Pennsylvania[J]. J Vet Diagn Invest, 2001, 13(1):89-91.
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共引文献403

同被引文献16

  • 1南善姬,赵节绪,林世和,江新梅,宋晓南.散发性Creutzfeldt-Jakob病患者10例prion基因研究[J].中华神经科杂志,2006,39(8):529-531. 被引量：1
  • 2樊丽超,赵节绪,王东升,左秀美,南善姬.散发性克-雅氏病患者脑脊液中抗炎性细胞因子IL-4水平的检测[J].中风与神经疾病杂志,2006,23(6):722-724. 被引量：3
  • 3Hilton DA,Ghani AC,Conyers L, et al. Accumulation of prion protein in tonsil and appendix: review of tissue samples[J]. BMJ, 2002,325(7365) :633-634.
  • 4van Everbroeek B, Green AJ, Vanmechelen E, et al. Phosphorylated tau in cerebrospinal fluid as a marker for Creutzfeldt-Jakob disease[-J~. J Neurol Neurosurg Psychiatry, 2002,73(1) : 79-81.
  • 5Green AJ,Thompson EJ,Stewart CE,et al. Use of 14-3-3 and other brain-specific proteins in CSF in the diagnosis of variant Creutzfeldt-Jakob disease[J]. J Neurol Neurosurg Psychiatry, 2001,70(6) :744-748.
  • 6Otto M, Wiltfang J, Cepek L, et al. Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease [J]. Neurology, 2002,58(2) : 192-197.
  • 7Goodall CA, Head MW, Everington D, et al. Raised CSF phospho-tau concentrations in variant Creutzfeldt-Jakob disease:diagnostic and pathological implications[J]. J Neurol Neurosurg Psychiatry,2006,77(1) : 89-91.
  • 8Buerger K,Otto M, Teipel SJ,et al. Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt-Jakob disease[J]. Neurobiol Aging, 2006,27 ( 1 ) : 10-15.
  • 9PuotiG,Giaccone G,Mangieri M,et al. Sporadic Creutzfeldt- Jakob disease:the extent of microglia activation is dependent on the biochemical type of PrPSc [J]. J Neuropathol Exp Neurol,2005,64(10):902-909.
  • 10Eikelenboom P, Bate C, Gool WA et al. Neuroinflammation in Alzheimer's disease and prion disease [J]. Glia,2002,40(2) :232-239.

引证文献1

中风与神经疾病杂志
2005年 第6期

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