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蛋白质转导域在医学中的研究与应用 被引量：2

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摘要 细胞膜脂质双分子层的非渗透特性阻止了一些肽类、蛋白质、核酸等生物活性物质进入细胞内,而血脑屏障也使大分子蛋白类药物难以到达中枢神经系统发挥疗效.这些天然屏障的存在为一些生物学机制研究和疾病基因治疗的应用带来了困难.而近来一种被称为蛋白质转导域(protein transduction domains,PTDS)的短肽由于其能携带生物活性物质有效的穿过细胞膜甚至血脑屏障,引起了众多学者的极大的关注.
作者 吴昊 吴江
机构地区 吉林大学第一医院神经内科
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2005年第6期566-568,共3页 Journal of Apoplexy and Nervous Diseases
关键词 蛋白质转导域 生物活性物质 细胞膜脂质 医学 中枢神经系统 血脑屏障 蛋白类药物 基因治疗 机制研究 分子层
分类号 R329 [医药卫生—人体解剖和组织胚胎学] R282.71 [医药卫生—中药学]
  • 相关文献

参考文献15

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共引文献7

同被引文献21

  • 1杨宇,吴江,杨欣,胡林森.NT4-NAP融合基因原核表达载体的构建及在大肠杆菌中的表达[J].中华神经科杂志,2004,37(3):260-261. 被引量：17
  • 2Angeles L.The blood-brain barrier:bottleneck in brain drug development[J].Neuro Rx,2005,2(1):3-14.
  • 3Magzoub M,Graslund A.Cell-penetrating peptides:small from inception to application[J].Q Rev Biophys,2004,37(2):147-95.
  • 4Brooks H,Lebleu B,Vives E.Tat peptide-mediated cellular delivery:back to basics[J].Adv Drug Deliv Rev,2005,57(4):559-577.
  • 5Zorko M,Langel U.Cell-penetrating peptides:mechanism and kinetics of cargodelivery[J].Adv Drug Deliv Rev,2005,57(4):529-545.
  • 6Deshayes S,Morris MC,Divita G,et al.Cell-penetrating peptides:tools for intracellular delivery of therapeutics[J].Cell Mol Life Sci,2005,62(16):1839-1845.
  • 7Magzoub M,Graslund A.Cell-penetrating peptides:small from inception to application[J].Q Rev Biophys,2004,37 (2):147-195.
  • 8Panagiotis S,Kabouridis S.Biological applications of protein transduction technology[J].Trends Biotechnol,2003,21 (11):498-503.
  • 9Temsamani J,Vidal P.The use of cell-penetrating peptides for drug delivery[J].Drug Discov Today,2004,9(23):1012-1019.
  • 10Loiler SA,Conlon TJ,Song S,et al.Targeting recombinant adeno-associated virus vectors to enhance gene transger to pancreatic islets and liver[J].Gene Ther,2003,10:1551-8.

引证文献2

二级引证文献7

中风与神经疾病杂志
2005年 第6期

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