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胃肠道间质瘤的研究进展 被引量:6

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摘要 胃肠道间质瘤(GIST)是消化道最常见的间叶源性肿瘤(GIMT).以前许多混杂有平滑肌纤维或神经束的上皮样肿瘤被误认为平滑肌瘤或神经源性肿瘤.1983年Mazur和Clark通过对以往的消化道间叶肿瘤进行回顾性研究,发现这组肿瘤既无平滑肌分化又无神经源性分化的抗原表达和超微结构,是一种非定向分化的间质瘤,类似未分化的幼稚间充质细胞,首先提出GIST的概念.近年国内外许多回顾性研究发现,既往病理学诊断为"平滑肌瘤"的病例,经病理切片的免疫组化和基因检测,其中许多属于间质瘤.
出处 《中华消化杂志》 CAS CSCD 北大核心 2005年第11期702-704,共3页 Chinese Journal of Digestion
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  • 1Seidal T, Edvardsson H. Expression of c-kit(CD117) and Ki67 provides information about the possible cell of origin and clinical course of gastrointestinal stromal tumors. Histopathology, 1999, 34:416-424.
  • 2Mazur MT, Clark HB. Gastric stromal tumors. Reappraisal of histogenesis. Am J Surg Pathol, 1983, 7: 507-519.
  • 3Kindblom LG, Remotti HE,Aldenborg F,et al. Gastrointestinal pacemaker cell tumor(GIPACT):gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. Am J Pathol,1998,152:1259-1269.
  • 4Hirota S,Isozaki K,Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science, 1998, 279:577-580.
  • 5Miettinen M, Lasota J. Gastrointestinal stromal tumors-definition,clinical,histological,immunohistochemical,and molecular genetic features and differential diagnosis. Virchows Arch,2001,438:1-12.
  • 6Tsuura Y, Hiraki H, Watanabe K, et al. Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma, and seminoma/dysgerminoma in human: immunohistochemical study of formalin-fixed, paraffin-embedded tissues. Virchows Arch, 1994, 424:135-141.
  • 7Arber DA,Tamayo R,Weiss LM. Paraffin section detection of the c-kit gene product(CD117) in human tissue:value in the diagnosis of mast cell disorders. Hum Pathol,1998,28:498-504.
  • 8Miettinen M, Virolainen M, Sarolmo-Rikala M. Gastrointestinal stromal tumors-value of CD34 antigen in their identification and separation from true leiomyomas and schwannomas. Am J Surg Pathol, 1995, 19: 207- 216.
  • 9Daimaru Y,Kido H,Hashimoto H,et al. Benign schwannoma of the gastrointestinal tract:a clinicopathologic and immunohistochemical study. Hum Pathol,1988,19:257-264.
  • 10Miettinen M, Sarlomo-Rikala M, Lasota J. Gastrointestinal stromal tumors: recent advances in understanding of their biology. Hum Pathol,1999,30:1213-1220.

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