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肌萎缩侧索硬化症的干细胞和基因治疗进展 被引量:1

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摘要 肌萎缩侧索硬化症(ALS)是一种运动神经元的进行性变性疾病。其发病机制未明,目前尚无十分满意的治疗方法。因此针对该病的治疗研究进展,我们将近年基因治疗(转入神经营养因子、基因沉默抑制突变SOD1表达等)和干细胞治疗的研究结果予以综述。
作者 黄慧 张成
出处 《国际神经病学神经外科学杂志》 2005年第6期504-507,共4页 Journal of International Neurology and Neurosurgery
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参考文献23

  • 1Alisky JM, Davidson BL. Gene therapy for amyotrophic lateral sclerosis and other motor neuron diseases. Hum Gene Ther,2000, 11(17): 2315-2329.
  • 2Azzouz M, Hottinger A, Paterna JC, et al. Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2. Hum Mol Genet, 2000, 9(5): 803 -811.
  • 3Azzouz M, Ralph GS, Storkebaum E, et al. VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature, 2004, 429(6990) : 413-417.
  • 4Kaspar BK, Llado J, Sherkat N, et al. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science,2003, 301 (5634) : 839-842.
  • 5Storkebaum E, Lambrechts D, Dewerchin M, et al. Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in arat model of ALS. Nat Neurosci, 2005, 8(1): 85-92.
  • 6Anna Ferri, Joshua RS, Michael PC, et al. Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease. Current Biology, 2003. 13(8) : 669-673.
  • 7Hannon GJ. RNA interference. Nature, 2002, 418 (6894):244-251.
  • 8Maxwell MM, Pasinelli P, Kazantsev AG, et al. RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells. Proc Natl Acad Sci USA, 2004, 101 (9) : 3178-3183.
  • 9Ralph GS, Radcliffe PA, Day DM, et al. Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model. Nat Med, 2005, 11 (4) : 429-433.
  • 10Raoul C, Abbas-Terki T, Bensadoun JC, et al. Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nat Med,2005, 11(4): 423 -428.

二级参考文献24

  • 1Dib M.Amyotrophic lateral sclerosis Progress and prospects for treatment.Drugs2003; 63:289-310
  • 2Rowland LP,Shneider NA.Amyotrophic lateral sclerosis.N Engl J Med 2001; 344:1688-700
  • 3Bensimon G,Lacomblez L,Meininger V,et al.A controlled trial of riluzole in amyotrophic lateral sclerosis.N Engl J Med 1994; 330:585-91
  • 4Miller RG,Mitchell JD,Lyon M,et al.Riluzole for amyotrophic lateral sclerosis(ALS)/motor neuron disease(MND).Cochrane Database Syst Rev 2001;CD001447
  • 5Morrison KE.Therapies in amyotrophic lateral sclerosis-beyond riluzole.Curr Opin Pharmacol2002; 2:302-9
  • 6Franklin RJ,Gilson JM,Franceschini IA,et al.Schwann cell-like myelination following transplantation of an olfactory bulb-ensheathin8 cell line into areas of demyelination in the adult CNS.Glia 1996; 17:217-24
  • 7Imaizumi T,Lankford KL,Burton WV,et al.Xenotransplantation of transgenic pig olfactory ensheathing cells promotes axonal regeneration in rat spinal cord.Nat Biotechnol 2000; 18:949-53
  • 8Karo T,Honmou O,Uede T,et al.Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord.Glia 2000; 30:209-18
  • 9Li Y,Field PM,Raisman G.Repair of adult rat corticospinal tract by transplants of olfactory ensheathing cells.Science 1997; 277:2000-2
  • 10Lu J,Feron F,Mackay-Sim A,et al.Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord.Brain 2002; 125:14-21

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