星形细胞瘤中Survivin、PTEN蛋白的表达及其相关性

The Expression of Survivin 、PTEN Protein and the Relationship between them in Astrocytomas

目的探讨星形细胞瘤中Survivin,PTEN蛋白的表达及它们之间的相关性。方法应用免疫组织化学S-P法检测Survivin,PTEN蛋白的表达水平,实验数据用SPSS12.0软件包进行统计。结果73例星形细胞瘤Survivin蛋白总阳性表达率为64.4%(47/73),随着肿瘤恶性程度加重,其阳性表达率逐渐增高(χ2=6.900,P=0.032);PTEN蛋白总阳性表达率为72.6%(53/73),随着肿瘤恶性程度加重,其阳性表达率逐渐下降(χ2=11.741,P=0.003);Survivin和PTEN蛋白表达与星形细胞瘤的病理分级密切相关。结论Survivin、PTEN蛋白阳性表达率与肿瘤的发展有关。随着肿瘤恶性程度的增高,Survivin蛋白阳性表达率逐渐增高,而PTEN的蛋白阳性表达率则逐渐下降。Survivin和PTEN蛋白在肿瘤中的表达可能存在负相关,在肿瘤的发展中发挥协同效应,联合检测Survivin和PTEN对于诊断星形细胞瘤,判断其恶性程度有一定价值。

Objective To investigate the expression of Survivin protein,PTEN protein and the relationship between them. Methods Immunohistochemical stains were performed to examine the expression level of survivn, PTEN protein in 73 astrocytomas. The software package SPSS 12.0 was used for statistical analysis. Results The Survivin protein positive rate in 73 astrocytic tumors was 64.4% （47/73）,and its positive rate was getting higher with the progress of tumor in malignancy（χ^2= 6. 900, P = 0. 032） ;The PTEN protein positive rate in 73 tumors was72.6% （53/73） ,and its positive rate was getting lower with the progress of tumor in malignancy（χ^2= 11. 741, P = 0. 003）;The Survivin protein and The PTEN protein were significantly correlated with the pathological grade of astrocytomas. Conclusion Survivin protein and PTEN protein were correlated with the progress of tumor; There may be negtive correlation between the expression of survivin and PTEN protein. Detection of Survivin protein together with PTEN protein was valuable for diagnosing astrocytmas.