冷水七醇提物抗炎作用的实验研究

Anti - inflammatory Effects of Ethanol Extract of Lmpatiens Omeiana

目的观察冷水七醇提物的抗炎作用。方法昆明种小鼠随机分为生理盐水组(给于等容积的生理盐水)、阿司匹林组(给药剂量为0．2g/kg)、冷水七醇提取物高剂量组和低剂量组(给药剂量分别为冷水七醇提取物 20g/kg和10g／kg),每组10只,各组灌胃给药。通过二甲苯致小鼠耳廓肿胀实验及醋酸致小鼠腹腔毛细血管通透性实验,观察冷水七醇提物对炎症的影响。结果冷水七醇提物高、低剂量组对二甲苯所致小鼠耳廓肿胀与生理盐水组比较有显著性差异(P<0．05,P<0．01),对醋酸致小鼠腹腔毛细血管通透性与生理盐水组比较也具有显著性差异(P<0．01)。结论冷水七醇提物具有明显的抗炎作用。

Objective To study the anti -inflammatory effects of extract of Lmpatiens Omeiana. Methods Forty mice were randomly divided into control group,aspirin group and two groups of Lmpatiens Omeiana at different does（ 10 mg and 20 mg·kg）. Ear edema induced by dimethylbenzene and abdominal capillary permeability by acetic acid in mice that was used to study the anti -inflammatory effects. Results Ethanol extract of Lmpatiens Omeiana （ 10 mg and 20 mg·kg） can inhibit ear edema（P 〈0.05 ,P 〈0.01 ）and reduce the abdominal capillary permeability（P 〈0.01）. Conclusion Ethanol extract of Lmpatiens Omeiana has anti -inflammatory effects.