特异性抗菌抗体喷剂与牛黄上清胶囊治疗急性咽炎的疗效比较

Comparation of Therapeutic Effect of Specific Hen Egg Immunoglobulin G Stomat-Spray of Anti-aureus Staphylococcus and Hemolytic Streptococcus with that of Niuhuangshangqing Capsules on the Patients with Acute Pharyngitis

目的:比较抗金黄色葡萄球菌及溶血性链球菌鸡卵黄IgG喷剂与牛黄上清胶囊治疗急性咽炎的临床疗效。方法:100例急性咽炎患者随机分为两组:治疗组50例和对照组50例。治疗组采用0.2%抗金黄色葡萄球菌及溶血性链球菌鸡卵黄IgG喷剂口腔喷雾治疗,对照组采用牛黄上清胶囊治疗。两组均5 d为1疗程。结果:治疗组治愈率26.0%、显效率34.0%、有效率28.0%、无效率12.0%、总有效率88.0%;对照组治愈率5.0%、显效率26.0%、有效率32.0%、无效率32.0%、总有效率68.0%,两组总有效率比较,差异有显著性(χ2=9.00,P<0.05)。结论:0.2%的抗金黄色葡萄球菌及溶血性链球菌鸡卵黄IgG抗体喷剂治疗急性咽炎疗效显著,安全、无毒副作用。

Objective.To compare the therapeutic effect of specific hen egg immunoglobulin G（IgY） stomat-spray of anti-S, aureus and S. hemolyticus with that of oral Niuhuangshangqing capsules on acute pharyngitis. Methods： The randomized trial was conducted on 100 patients with acute pharyngitis. Experimental group of 50 patients received 0.2% stomat-spray of specific hen egg immunoglobulin G of anti-S, aureus and S. hemolyticus 8 sprays per time,4 times daily for 5 days. Control group of 50 patients took Niuhuangshangqing capsules orally 3 tablets per time, 2 times daily for 5 days. The therapeutic effects were objectively evaluated 5 days later by the decreased scores based on both the symptoms and physical signs. Results： In experimental group the cure rate,striking effective rate, effective rate, and ineffective rate were 26.0% （13/50）, 34.0% （17/ 50）, 28.0% （14/50）, and 12.0% （6/50）, respectively, with a total effective rate of 88. 00% （44/ 50）. In control group the cure rate,striking effective rate,effective rate,and ineffective rate were 10. 0%（5/50） ,26.0%（13/50） ,32.0%（16/50）,and 32.0%（16/50） ,respectively,with total effective rate of 68.0%（34/50）. The difference between the two groups was significant （X^2= 9.00,P〈0.05）. There were no side effect or toxic effect and no allergic reaction in experimental group. Conclusion：The stomat-spray of specific hen egg immunoglobulin G of anti-S, aureus and S. hemolyticus is a safe and effective agent in treating acute pharyngitis.