原发性食管小细胞癌临床分析

Retrospective analysis of 20 cases of primary esophageal small cell carcinoma

目的探讨原发性食管小细胞癌的临床特点、治疗及预后。方法回顾性分析20例原发性食管小细胞癌患者的临床资料。结果局限期患者单纯手术、单纯化疗、单纯放射治疗、手术+化疗、化疗+放射治疗的中位生存时间分别为14,14,6,18,16个月;广泛期患者单纯化疗(2例)、化疗+放射治疗(2例)中位生存时间分别为6和8个月。全组的中位生存期为12个月,生存最长者已达72个月。而未治疗的广泛期患者仅存活2个月。结论对于原发性食管小细胞癌,应采用以化疗为主的综合治疗。

Objective To investigate the clinical characteristics,management and prognosis of primary esophageal small cell carcinoma （PESCC）. Method Twenty patients with PESCC including fourteen males and six females were analyzed retrospectively. Results The numbers of patients in the limited stage who were treated with surgery, chemotherapy, radiotherapy, surgery combined with chemotherapy and radiotherapy combined with chemotherapy were 5,5,3,2 and 4 and they had the median survival time of 14,14, 6,18 and 16 months, respectively. Four patients of extended stage received chemotherapy （2 patients） and radiotherapy combined with chemotherapy （2 patients） had the median survival time of 6 and 8 months. The median survival time of all the patients was 12 months with the longest survival time of 72 months. A patient of the extended stage without any treatment only lived 2 months. Conclusion Patients with PESCC should be managed by chemotherapy-based combination therapy.