法尼西基转移酶抑制剂R115777治疗恶性血液病的研究现况

Present Status of the Study and Clinical Evaluation of Farnesyl Transferase Inhibitor-R115777 Used for Malignant Blood Diseases

目的:介绍法尼西基转移酶抑制剂(farnesyl transferase inhibitor,FTI)R115777的研究现状,并评价其临床疗效和安全性。方法:查阅近期相关文献进行评价。结果与结论:R115777是一种新近开发的抗恶性疾病的靶向治疗药物,能通过抑制法尼西基转移酶而影响恶性细胞的存活分化与增殖,对某些恶性血液病,特别是髓性恶性增生性血液病有特定的疗效。

OBJECTIVE： To introduce the present status of the study of farnesyl transferase inhibitor- R115777 and evaluate its clinical curative effect and the safety. METHODS： By looking up recent literatures for reviewing. RESULTS ＆ CONCLUSION： R115777 is a newly exploitated targeted therapy drug for malignant diseases. It can affect survival differentiation and proliferation of malignant cells by inhibiting farnesyl transferase enzyme. It has special efficacy on some malignant blood diseases, especially on man＇owing malignant hyperplastic blood disease.