3种制药用水处理工艺评价

Evaluation of3Kinds of Water for Pharmaceutical Purposes Processing Techniques

目的:介绍适合医院制剂室制药用水处理的工艺与设备。方法:依据《中国药典》相关标准并以电导率为指标,评价3种工艺制备的纯化水的水质;同时以源水的利用率、操作的方便程度、对环境的污染等因素综合评价3种水处理工艺的优劣。结果:3种工艺制备的纯化水均符合《中国药典》相关标准要求,其中离子交换法与一级反渗透组合工艺制备的纯化水水质最高,二级反渗透与电法去离子组合系统制备的纯化水水质次之;将3种工艺制备的纯化水进一步蒸馏,可制备出符合《中国药典》标准的注射用水。结论:综合水质、源水的利用率、操作的方便程度、对环境的污染等因素,二级反渗透与电法去离子系统组合为最佳的纯化水生产工艺;多效蒸馏法是制备注射用水的主流工艺。

OBJECTIVE： To introduce water processing treatment technology and equipment for hospital manufacturing laboratory.METHODS：According to the relevant standards recorded in China Pharmacopoeia and electric conductivity,water quality of purified water manufactured by 3 kinds of techniques were evaluated.The advantages and disadvantages of these techniques were compared with regard to the utilization of source water, convenience of operation, environmental pollution, and so on.RESULTS： Purified water manufactured by these 3 kinds of techniques all met the standards recorded in China Phar- macopoeia, best quality was obtained by the technique of combining ion exchange with first order reverse osmosis, the next in order is obtained through the combination of second order reverse osmosis with electrode ionization（EDI） .The purified water could be distilled to be water for injection which meets the standard in China Pharmacopoeia .CONCLUSION： Combination of second order reverse osmosis with EDI is the optimal water processing technique considering quality of purified water, utiliza- tion of source water, convenience of operation, environmental pollution and so on. Multiple distillation technology is the main artwork to prepare water for injection.