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EMS1基因与肿瘤 被引量：4

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摘要 EMS1基因(chromosom e eleven,band q13,m amm ary tumour and squamous cell carc inom a-assoc iated gene1)定位于人类染色体11q13。该基因编码产物cortactin(cortical actin-b ind ing prote in)是一种位于细胞皮质区的肌动蛋白结合蛋白,参与细胞骨架系统的调控,细胞外信号转导以及细胞黏附等过程。研究表明EMS1基因与许多肿瘤的侵袭和转移有关。
作者 林敏 谢海龙 苏琦
机构地区 南华大学肿瘤研究所
出处 《国际病理科学与临床杂志》 CAS 2005年第6期481-484,共4页 Journal of International Pathology and Clinical Medicine
关键词 EMS1基因 肿瘤 转移
分类号 R730.2 [医药卫生—肿瘤]
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参考文献26

  • 1Schuuring E, Verhoeven E, Mooi WJ, et al. Identification and cloning of two overexpressed genes, U21 B31/PRAD1 and EMS1, within the amplified chromosome 11 q13 region in human carcinomas[ J ].Oncogene, 1992,7 (2) :355-361.
  • 2Van Rossum A, Schuuring-Scholtes E, Seggelen V, et al. Comparative genome analysis of cortactin and HS1 : the significance of the F-actin binding repeat domain[ J]. BMC Genomic,2005,6( 1 ) :15.
  • 3Schuuring E, Verhoeven E, Litvinov S, et al. The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a vsrc substrate and is located in cell-substratum contact sites[J]. Mol Cell Biol, 1993,13(5) :2891-2898.
  • 4Wu H, Parsons JT. Coractin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex[J]. J Cell Biol,1993,120(6) : 1417- 1426.
  • 5Van Rossum A, De Graaf JH, Schuuring-Schohes E, et al. Alternative splicing of the actin binding domain of human cortactin affects cell migration[ J]. J Biol Chem,2003,278 (46) :45672-45679.
  • 6Organdy CJ, Musgrove EA, Hui R, et al. Cyclin D1, EMS1 and 11q13 amplification in breast cancer [ J ]. Breast Cancer Res Treat,2003,78 (3) :323-335.
  • 7Li Y, Tondravi M, Lin J, et al. Cortactin potentiates bone metastasis of breast cancer cells[ J]. Cancer Res, 2001,61 ( 18 ) : 6906-6911.
  • 8Alavi S, Namazie A, Calcaterra TC, et al. Clinical application of fluorescence in situ hybridization for chromosome 11q13 analysis inhead and neck cancer[ J]. Laryngoscope, 1999,109(6) : 874-879.
  • 9Rodrigo JP, Suarez C, Gonzalez MV, et al. Variability of genetic alterations in different sites of head and neck cancer [ J ]. Laryngoscope, 2001,111 (7): 1297-1301.
  • 10Rodrigo JP, Garcia LA, Ramos S, et al. EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck [ J ]. Clinical Cancer Research, 2000, 6 ( 8 ) : 3177-3182.

同被引文献28

  • 1Man-Li Luo Ming-Rong Wang.CTTN (EMS1): an oncogene contributing to the metastasis of esophageal squamous cell carcinoma[J].Cell Research,2007,17(4):298-300. 被引量：3
  • 2李晓杰,谢海龙.肝细胞癌分子遗传学研究进展[J].湘南学院学报（医学版）,2007,9(2):75-77. 被引量：2
  • 3Schuuring E, Verhoeven E, Mooi WJ, et al. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas [J]. Oncogene, 1992, 7(2):355-361.
  • 4Hattori Y, hoh H, Uchino S, et al. Immunohistochemical detection of K-sam protein in stomach cancer[ J ]. Clin Cancer Res, 1996, 2 (8) : 1373 - 1381.
  • 5van Rossum AG, Schuuring-Scholtes E, van Buuren-van Seggelen V. Comparative genome analysis of coritactin and HS1 : the significance of the F-actin binding repeat domain [ J ]. BMC Genomic, 2005, 6 (1):15.
  • 6Schuuring E, Verhoeven E, Litvinov S, et al. The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites[J]. Mol Cell Biol, 1993,13(5) :2891 - 2898.
  • 7Wu H, Parsons JT. Coractin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex[J]. J Cell Biol,1993, 120(6) : 1417 - 1426.
  • 8Rodrigo .IP, Suarez C, Gonzalez MV, et al. Variability of genetic alterations in different sites of head and neck cancer[J]. Laryngoscope,2001,111(7) : 1297 - 1301.
  • 9Rodrigo LIP, Garcia LA, Ramos S, et al. EMS1 gene amplification correlates with poor prognosis in squamous cell carcinomas of the head and neck[J]. Clinical Cancer Research, 2000,6(8) : 3177 - 3182.
  • 10Takes RP,Baatenburg de Jong RJ,Schuuring E.Markers for assessment of nodal metastasis in laryngeal carcinoma[J].Arch Otolaryngol Head Neck Surg,1997,123(4):412-419.

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国际病理科学与临床杂志
2005年 第6期

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