森田疗法与西酞普兰联合治疗强迫症的对照研究

A Controlled Study of Morita Therapy Combined with Citalopram in the Treatment of Obsessive-Compulsive Disorder

目的:探讨森田疗法与西酞普兰联合治疗强迫症的的疗效及安全性。方法:将56例强迫症患者随机分为观察组和对照组,每组28例。观察组采用森田疗法和西酞普兰治疗,对照组单纯以西酞普兰治疗,疗程2个月。采用Y-BOCS、CGI-SI、HAMD、TESS等量表评定疗效及安全性。结果:在治疗后第4、8周及半年随访时,观察组Y-BOCS、CGI-SI、HAMD等量表评分均显著低于对照组(均P<0.05),两组不良反应比较差异无显著性(P>0.05)。结论:森田疗法与西酞普兰联合治疗强迫症的疗效优于单用西酞普兰。

Objective ： To evaluate the efficacy and safety of Morita therapy combined with citalopram in the treatment of obsessive-compulsive disorder（OCD）. Methods： Fifty-six patients with OCD were randomized to two groups. The patients （N=28） in observed group were treated with Morita therapy combined with citalopram. The patients （N=28） in control group were treated with citalopram alone. The efficacy and safety were assessed with Y-BOCS, CGI-SI, HAMD and TESS scales. Results ： The scores of Y-BOCS, CGI-SI and HAMD scales in observed group were significantly lower than that in control group at the end of 4 weeks, 8 weeks and 6 month after the treatment （P〈0.05, respectively）. There was no significant difference in side effects between the two groups （P〉0.05） Conclusion： Morita therapy combined with citalopram was more effective than citalopram mono-therapy in the treatment of OCD.