期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

成骨细胞分化与信号转导研究进展 被引量：3

Progress in reseach of osteoblast differentiation and signal transduction
下载PDF
导出
摘要 成骨细胞在骨的生长、发育及形成过程中起重要作用,其分化受严格调控,通过多种信号途径实现对成骨细胞的定向分化。综述了G蛋白信号调节因子、BMP/Smads、MAPK、PI3-k以及细胞因子等信号通路在成骨细胞定向分化方面的研究进展。 Osteoblast plays an important role in bone growth, development, and formation. Osteoblast differentiation is controlled by a varity of signals pathways including G protein, BMP/Smads, MAPK, PI3-k pathways and many cytokines. Recently progress on how these signal transduction pathway regulate osteoblast differentiation is reviewed in this paper.
作者 赵红斌 张西正 郭勇
机构地区 军事医学科学院卫生装备研究所
出处 《国外医学（生物医学工程分册）》 2005年第6期344-347,共4页 Foreign Medical Sciences(Biomedical Engineering Fascicle)
基金 军事医学科学院创新基金资助项目(CX20040703)
关键词 成骨细胞 分化 信号转导 osteoblast differentiation signal transduction
分类号 R329 [医药卫生—人体解剖和组织胚胎学]
  • 相关文献

参考文献19

  • 1De Vries L,Zheng B,Fischer T,et al.The regulator of G proteins signaling family[J].Ann Rev Pharmacol Toxicol,2000,40:235-271.
  • 2Kannan T,David LH,Miles RR,et al.Analysis of regulator of G-Protein signaling-2(RGS-2) expression and function in osteoblastic cells[J].J Cell Biochem,2002,85:837-850.
  • 3Hassel S,Schmitt S,Hartung A,et al.Initiation of Smad-dependent and Smad-independent signaling via distinct BMP-receptor complexes[J].J Bone Joint Surg Am,2003,85:44-51.
  • 4Ying SX,Hussain ZJ,Zhang YE.Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2 induced osteoblast conversion by targeting Smad5 for degradation[J].J Biol Chem,2003,278:39029-39036.
  • 5Zhao Ming,Qiao Mei,Stephen EH,et al.Smurt1 inhibits osteoblast differentiation and bone formationin vitro and in vivo[J].J Biol Chem,2004,279:12854-12859.
  • 6Gallea S,Lallemand F,Atfi A,et al.Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells[J].Bone,2001,28(5):491-498.
  • 7Lemonnier J,Ghayor C,Guicheux J,et al.Protein kinase C-independent activation of protein kinase D is involved in BMP-2-induced activation of stress mitogen-activated protein kinases JNK and p38 and osteoblastic cell differentiation[J].J Biol Chem,2004,279:259-264.
  • 8Nishitai G,Shimizu N,Takahiro T.Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells[J].J Biol Chem,2004,279:1621-1626.
  • 9Komori T,Kishimoto T.Cbfal in bone development[J].Curr Opin Genet Dev,1998,8:494-499.
  • 10Nishimura R,Hata K,Harris SE,et al.Core-binding factor α1(Cbfa1)induces osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5[J].Bone,2002,31:303-312.

同被引文献26

  • 1邱明才.骨结构与骨代谢[J].医用生物力学,1995,10(4):253-256. 被引量：1
  • 2卞琴,王拥军,施杞.粘附斑激酶信号转导与串话研究进展[J].中西医结合学报,2005,3(6):495-497. 被引量：3
  • 3Yong-Jun Wang,Chong-Jian Zhou,Qi Shi,Nathan Smith,Tian-Fang Li.Aging delays regeneration process after sciatic nerve injury in rats.Journal of Neurotrauma,2007,24(5):885-894.
  • 4Gruber HE,Hanley EN.JrAnalysis of aging and degeneration of the human interver-tebraldisc.Comparison of surgical specimens with normal controls[J].Spine,1998,23(7):751.
  • 5Ying SX,Hussain ZJ,zhang YE.Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by taigeting Smad5 for degradation[J].J BiolChen,2003,278:39029-39036.
  • 6Gallea S,Lallemand F,Atfi A,et al.Activation of mitogen-activated protein kinase is in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells[J].Bone,2001,28(5):491-498.
  • 7Lunn JA,Rozengurt E.Hyperosmotic stress induces rapid focal adhesion kinase phosphorylation at tyrosines 397 and 577.Role of Src family kinases and Rho family GTPases[J].J Biol Chem,2004,279(43):45266-45278.
  • 8Guan JL.Role of focal adhesion kinase in integrin signaling[J].Int J Biochem Cell Biol,1997,29(8-9):1085-1096.
  • 9Kim SJ,Hwang SG,Shin DY,et al.p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 viaNFkappa B-dependent transcription and stabilization by serine 15 phosphorylation[J].J BiolChem,2002,277(36):33501-33508.
  • 10Chin M,Ng T,Tom WK,et al.Repair of alveolar clefts with recombinant human bone morphogenetic protein (rhBMP-2) in patients with clefts[J].J Craniofac Surg,2005,16(5):778-789.

引证文献3

二级引证文献2

国外医学（生物医学工程分册）
2005年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部