医用聚氨甲酸乙酯栓堵对兔输卵管影响的初步观察

Preliminary experimental studies of medical polyurethane on rabbit oviducts

目的研究聚氨甲酸乙酯（ＭＰＵ）栓堵对兔输卵管形态和分泌功能的影响，并探讨其可复性。方法直视下将ＭＰＵ注入兔输卵管内进行栓堵，１２ｗ后测定输卵管液中元素浓度、葡萄糖和总蛋白含量，并用光镜、电镜观察输卵管形态的改变。结果１．栓堵后输卵管液中钙、锌、钠等元素和总蛋白量显著下降（Ｐ＜０．０５），钾、铁、铜和锰等元素差异无显著性（Ｐ＞０．０５）。２．栓堵处输卵管腔扩张，皱襞变平，但未见粘膜坏死或脱落。透射电镜下见分泌细胞内线粒体肿张，内质网扩张，分泌颗粒减少；纤毛细胞的纤毛变短，稀疏排列。结论ＭＰＵ栓堵对输卵管影响轻微，有复通的可能。

To study the effects on the morphology and secretory activity of fallopian tubes occluded by the plugs of medical polyurethane (MPU ).Methods Female adult rabbit's oviducts were occluded by injection of MPU, 12weeks later , the concentrations of elements ,total protein(TP) and glucose of oviduct fluid were measured and the morphology of fallopian tubes was observed.Results 1. After occlusion , the elements of Na, Ca, Zn and TP were all significantly lower than those of normal group (P<0. 05 ), However, the contents of Cu, Mn and glucose were not signifcantly different (P>0. 05 1 . 2. It was found, under light microscope,that the lumen of the oviducts was enlarged, the mucosal folds were flattened, the walls were thinned, no mucosal necrcois, increased of fibrosis, infiltration of inflammatory cells were obseved. By electron-microsocopic examinations, cilia of the ciliate cells were found to be shortened, deciliated and thinned. In the secretory cells, the mitochondria showed expanded, the rough endoplasmic reticula dilated and the amount of secretory granules decreased.Conclusion The occlusion of rabbit oviduct by MPU presents morphological and secretory effects which may have a reversibile tendency after removal of the plugs.