供者抗原门静脉输注对大鼠皮肤移植存活的影响

Protal Vein Injection of Donor-specific Antigen prolong Survival of Sinks Transplantation in Rat

目的:探讨特异性抗原诱导免疫耐受的作用。方法:通过门静脉途径输注脾细胞、骨髓细胞,观察皮肤移植模型。结果:受体接受供体脾细胞(DSC)、骨髓细胞(DBMC)及同时接受(DSC)和(DBMC)后能诱导受体产生免疫耐受。结论:肝脏特殊的免疫功能在免疫耐受产生中起重要作用。

Objective： To find whether the donor-specific antigen can induce immunological tolerance. Metheds： A rat model of skins transplantation was established and different donor spleen cell and bone marrow cell were infused through the portal vein. Results： DSC,DBMC and DSC＋DBMC could induce the specific tolerance in receptors. Conclusions： The immunological tolerance correlated with the special immunological function of the liver and it may play an important role.