不同海拔地区正常男性成年人血浆胃泌素、胃动素水平变化

Changes of Serum Level of GAS and MTL in Healthy Adults at Different Altitude

目的:研究正常人在不同海拔地区,血中胃泌素(GAS)、胃动素(MTL)水平的变化,进而探讨人进入高原后机体消化系统的适应性及胃黏膜病变发生的可能机制。方法:选取广州(海拔2m),西宁(海拔2260m),青藏铁路雁石坪(海拔4750m)三个不同海拔高度正常成年男性共62例。分别采血,用放射免疫法测定胃肠激素水平。结果:三个地区正常男性成年人血中GAS的含量分别为25.62ng/L±2.79ng/L、27.37ng/L±5.25ng/L、62.33ng/L±98.64ng/L(与广州比P<0.05,与西宁比P>0.05);MTL的含量为224.12pg/ml±115.36pg/ml、257.61pg/ml±155.70pg/ml、245.22pg/ml±113.72pg/ml,随着海拔升高其血浆水平有变化,但经统计学处理差别无显著性(P>0.05)。结论:随着海拔升高正常成年男性血中GAS和MTL的含量均有明显升高。提示:MTL的含量的变化可能与人体高原胃肠的适应性有密切关系,而GAS的改变与高原胃肠病的高发生率有密切关系。

Objective： To compare the serum level of gastrin（GAS） ,motilin（MTL） in healthy male adults at different altitude to determine if the altitude hypoxia affects the function of digestive system. Methods： 62 subjects, who were healthy mature men, were recruited from Guangzhou （2m altitude）, Xining （2 260m） and Qing-Tibet railway Yanshiping （4 750m）. The serum levels of gut hormones were measured by radioimmunoassay. Resuits： The level of GAS in Guangzhou, Xining and Yanshiping was 25.62 ng/L ±2.79ng/L, 27.37 ng/L ±5. 25ng/L,62.33 ng/L ± 98.64ng/L respectively（ P 〈 0.05 vs Guangzhou, P 〉 0.05 vs Xining）. The level of MTL was 224.12pg/ml ±115.36pg/ml,257.61pg/ml ± 155.70pg/ml and 245.22pg/ml ± 113.72pg/ml, respectively. Although higher level of MTL with higher altitude no statistic difference among groups. （P 〉 0.05 ）. Conclusions： The serum levels of GAS and MTL in healthy mature man were elevated with the altitude. The finding indicated that change of MTL and GAS could associate with the habituation and diseases of digestive system in human at high altitude.