栓塞化疗合并注射无水乙醇治疗原发性肝癌(附112例报告)

Treatment of combined trans-arterial chemoenbolization and percutaneous ethanol injection for hepatocellular carcinoma-a report of 112 cases

目的探讨栓塞化疗合并瘤内注射无水乙醇治疗原发性肝癌(简称肝癌)的疗效。方法回顾性分析采用动脉插管栓塞化疗(TACE)与经皮注射无水乙醇(PEI)序贯治疗112例肝癌患者(研究组),并与同期病例相似的70例肝癌(对照组)单纯采用TACE治疗的疗效相比较。结果首次治疗后AFP下降有效率(CR+PR)研究组为68.8%,对照组为30.0%;肿瘤体积缩小率(CR+PR)研究组为78.6%,对照组为34.3%。第2疗程AFP下降有效率(CR+PR)研究组为77.8%,对照组为28%;肿瘤体积缩小率(CR+PR)研究组为80.5%,对照组为45.0%。以上两组间差异均有统计学意义(P均<0.05)。结论TACE合并PEI治疗肝癌可以提高疗效,是合理有效的治疗方法。

Objective To investigate the efficacy of treatment of combined trans-arterial chemoembolizatin and percutaneous ethanol injection for hepatocarcinoma. Methods A retrospective analysis of 112 cases with hepatocarcinoma （studied group） received the sequent treatment of combined trans-arterial chemoembolization （TACE） and percutaneous ethanol injection （PEI）, and comparing with 70 cases with hepatocarcinoma （ control group） that received TACE only. Results After treating for the first time, with level of AFP declined, （CR ＋ PR） rate of the studied group was 68.8 % and that of control grouup was 30.0 %, and the reduction in tumor size （CR ＋ PR） of the studied group was 78.6 % and that of control group was 34.3 %. After second time treating , with level of AFP declined, （CR ＋ PR） rate was 77.8 % in the studied group and 28, 0 % in control group, and the reduction in tumor size （CR ＋ PR） was 80.5 % in the studied group and 45.0% in control group.Conclusion TACE and PEI sequent therapy is an effective treatment for hepatocarcinoma.