摘要
目的:初步探讨紫杉醇联合异环磷酰胺治疗晚期非小细胞肺癌的疗效及毒副作用.方法:用紫杉醇联合异环磷酰胺治疗晚期非小细胞肺癌31例.紫衫醇(175 mg/m2d1)静滴3 h,异环磷酰胺(1.5 g/m2 d1～3)静滴6～8 h.21 d为1个周期,连续2～6个周期.结果:完全缓解1例,部分缓解7例,稳定17例,进展6例.总有效率25.8%.毒副作用主要有WBC减少,脱发,恶心、呕吐,肌肉酸痛.结论:紫杉醇联合异环磷酰胺治疗晚期非小细胞肺癌疗效肯定,毒性可以耐受.
Objective： To evaluate the curative effect and toxic side-effects of paclitaxel combined with ifosfamide in the treatment of advanced non-small cell lung cancer. Methods： Thirty-one patients were injected with intravenous infusion of paclitaxol（175 mg/m^2 dl ）for 3 hours, and ifosfamide（1.5 g/m^2 dl.3）for 6-8 hours. Each cycle was 21 days. Results： The overall effective rate was 25.8% with complete remission of one case and partial remission of 7 cases. The main toxic side-effets were leucopenia, alopenia, nausea and vomiting, muscle aching pain. Conclusion： Paclitaxel combined with ifosfamide is the effective method for advanced non-small cell lung cancer.
出处
《汕头大学医学院学报》
2005年第4期208-209,共2页
Journal of Shantou University Medical College
关键词
非小细胞肺癌
联合化疗
紫杉醇
异环磷酰胺
non-small cell lung cancer
combined chemotherapy
paclitaxel
ifosfamide
