补肾活血法对肾性骨病患者全段甲状旁腺素与骨特异性碱性磷酸酶的影响

Influences of Therapy of Reinforcing Kidney and Activating Blood on Parathormone and AlkalinePhos phatase of Patient with Renal Osteopathy

目的探讨补肾活血法对慢性肾功能衰竭肾性骨病(RBD)患者甲状旁腺功能亢进及骨代谢异常的改善作用及其机理,并与单纯补肾法相对比。方法采用交叉设计方法比较补肾活血法与单纯补肾法对肾性骨病患者全段甲状旁腺激素(I-PTH)、骨特异性碱性磷酸酶(BAP)指标的影响。结果补肾活血法治疗后血清I-PTH、BAP水平较治疗前均有所下降;单纯补肾法治疗后血清I-PTH、BAP水平较治疗前均显著升高。结论补肾活血中药可以缓解RBD患者甲状旁腺功能亢进的状态,有效改善骨代谢异常,从而延缓RBD的进展。

Objective To discuss the effect of the therapy of reinforcing kidney and activating blood on hyperparathyroidism and abnormal bone metabolism in the patients with renal osteopathy induced by chronic renal insufficiency （CRI）, investigate the mechanism of this therapy and compare it with the therapy of reinforcing kidney only. Method A cross-design method was used to compare the influences of the therapy of reinforcing kidney and activating blood on parathormone （I-PTH）, bone alkaline phosphatase （BAP） in the patients with that of the therapy of reinforcing kidney only. Result The levels of serum I-PTH and BAD decreased after the treatment with the therapy of reinforcing kidney and activating blood, but that increased obviously after the treatment with the therapy of reinforcing kidney only. Conclusion The therapy of reinforcing kidney and activating blood can alleviate hyperparathyroidism, relieve abnormal bone metabolism and delay the development of renal osteopathy.