血塞通注射液对糖尿病合并脑梗死患者血液流变学的影响

Influence of Xuesaitong Injection on Hemorrheology of Patient with Diabetes Combined with Cerebral Infarction

目的观察血塞通注射液对糖尿病合并脑梗死患者血液流变学指标的影响。方法以自身对照的方法,观察46例糖尿病合并脑梗死患者接受血塞通注射液治疗前后的血液流变学指标的变化。结果血塞通注射液治疗前后,男性组红细胞压积、低切变率全血粘度、血浆粘度、红细胞变形能力及纤维蛋白原均有明显变化,存在显著差异(P<0.05),特别是低切变率下的红细胞变形能力的变化具有显著差异(P<0.01);女性组血浆粘度、全血粘度、红细胞变形能力及纤维蛋白原均有明显变化,具有显著差异(P<0.05)。结论血塞通注射液能显著降低纤维蛋白原及低切变率下的全血粘度和血浆粘度,改善脑缺血,并缓解因梗死引起的中枢与肢体的临床症状。

Objective To observe the influence of Xuesaitong Injection （XI） on hemorrheology of patient with diabetes combined with cerebral infarction. Method The autocontrol method was used to observe the index changes changes of hemorrheology in 46 patients before and after the treatment with XI. Result There were remarkable in hematocrit （Hct）, whole blood viscosity at a low shear rate, erythrocyte deformation and fibrinogen in the male group after the injection. The difference was significant （P〈0.05）, especially the change of erythrocyte deformation at a low shear rate was different significantly （P〈0.01）. There were also remarkable changes in plasma viscosity, whole blood viscosity, erythrocyte deformation and fibrinogen in the female group. The difference was significant （P〈0.05）. Conclusion XI can obviously decrease fibrinogen, whole blood viscosity and plasma viscosity at a low shear rate, alleviate cerebral ischemia, and relieve central and limb symptoms induced by cerebral infarction.