不同剂量米索前列醇用于晚期妊娠引产的临床观察

A Clinical Study on Different Dosage of Misoprostol on Induction for Labor in Late Pregnant Phase.

目的探讨米索前列醇用于足月引产的最佳剂量,以减少副作用,提高阴道分娩的成功率.方法选择有引产指征,无禁忌症的初产妇500例,年龄20～35岁,妊娠37～42W.随机分为A组(米索μgq3h)和B组(米索50μgq3h)各250例.两组均为阴道后宫隆置药.结果两组均有促宫颈成熟作用,且效果明显,A组总有效率93.2%,B组总有效率95.2%,两组之间差异无统计学意义(P＞0.05),但A组宫缩过强及羊水Ⅲ度污染的发生率均低于B组,差异有统计学意义(P＜0.01,P＜0.01).结论25μg和50μg米索前列醇应用晚期妊娠引产同样有效,但A组母婴更安全.

Objective To explore the best dosage of misoprestol on induction of labor in late pregnant phase. Methods Five-hundred primiparas （at 37-42 weeks） with single pregnancy, vertex present were selected for study groups, in which all cases indicated for labor induction without contra-indication. They were randomly divided into group A （treated by 25μg of misoprostiol）, and group B （50μg of misoprsotol）. Misoprostol were placed in the posterior vaginal fomix every 3 hours until uterine contractions occur 3 times per 10 minutes. Results Induced labor effective rates in group A and group B were 93.2% and 95.2% respectively （P〉0.05）. The incidence of llypertonic uterine contraction or amniotic contamination in group A was lower than that of group B. Conclusion 25μg of misoprostol is the same effective as 50μg of misoprostol for induced labor in the late phase of pregnancy, whereas induced labor in the phase with low dosage of misoprostol is more safe.