急性白血病患者预后相关的临床病理学因素

Clinicopathological factors correlate to the prognosis of acute leukemia

急性白血病(acuteleukemia,AL)是血液系统常见的恶性肿瘤,其自然病程仅2～4个月。现在AL达到化疗完全缓解(completeremission,CR)已不困难,提高患者长期生存(overallsurvival,OS)率已成为急需解决的课题。近20年来,国内成人急性淋巴细胞白血病(acutelymphaticleukemia,ALL)和急性髓性细胞白血病(AcuteNonlymphaticLeukemia,ANLL)患者中20%～30%可长期无病生存,但能够CR超过5年以上且OS的病例不多,CR后OS达10年以上者更少。我们对近10年来文献报道的425例急性白血病长期存活患者的临床资料加以分析,以探讨影响AL患者长期存活的多个因素及其相互关系,以期客观有效地指导临床治疗,提高患者的长期生存率。

Acute leukemia （AL） is one of the most common cancergenious disease of blood system, which has a relatively short disease duration. In recent years, chemotherapy has become a common way of treating AL and has achieved complete remission （CR） without difficulty. Acute lymphatic leukemia （ALL） has a CR ratio of 30%, a little higher than CR ratio of acute non-lymphatic leukemia （ANLL）. Though with all the success, long term survival rate of more than 5 years is still lower and overall survival （OS） of reaching to 10 years is even fewer. This article focuses on 495 long-term survival AL cases reported in the past ten years in order to shed light on relations among certain factors and to help physicians deal with their clinical practices for long-term survival ratio increment.