记忆储存的分子机制

Molecular mechanism for memory storage

目的:综述国内外有关记忆储存分子机制的研究概况,以期进一步了解记忆储存的机制和进展。资料来源:利用计算机检索1976/2005Medline相关文献,检索词为“memory;storage”,限定语言种类为English,通过国家智库检索中文的文献,检索词为“记忆,储存”,限定语言种类为中文。资料选择:选择与记忆储存分子机制相关的文献,对与记忆相关形态结构的文章不予采纳。资料提炼:共收集到相关文献56篇与记忆储存有关,其中13篇实验文献根据相应标准采纳,其余文献均被排除。资料综合:中枢系统突触的长时程抑制和长时间增强是研究学习和记忆神经机制的核心问题。长时程抑制起着不断纠正操作错误的重要作用。长时程增强效应与记忆能力有明显的相关性。但完整的记忆储存理论还没建立。结论:目前的研究表明记忆储存的分子机制是复杂的,完整的理论体系还没建立,还需要各学科的融合继续进一步的研究。

OBJECTIVE： To further understand the mechanism and process of memory storage on the basis of summarizing the survey about molecular mechanism on memory storage at home and abroad, DATA SOURCEs： An online search of Medline database was applied with the keywords of ＂memory, storage, mechanism＂ to identify related articles published in English from January 1994 to April 2004. Meanwhile, Chinese articles published between January 1994 and April 2004 were identified on China National Knowledge Infrastructure （CHKI）, and the keywords were ＂memory, storage, mechanism＂. STUDY SELECTION： After preliminary search, the literatures related to memory and mechanism were selected, and then the obvious non-randomized trial studies were excluded. Finally the full-texts of the selected literatures were scanned. DATA EXTRACTION： Totally 56 articles about the randomized or non- randomized trials related to memory, storage and mechanism were collected, and 13 were in accordance with the inclusive criteria, others were exeluded. DATA SYNTHESIS： Long-term depression and long-term potential are the essential problem concerning molecular on memory storage. Long-term depression has an important role of correcting operational wrongs. Long- term potential has closely associated with memory abilities, but the complete system of memory theory has not been established. CONCLUSION： The results of the current study indicate that the molecular mechanism of memory storage is complex, and still not clear, which needs the melting of other subjects for further study.