造血干细胞移植治疗恶性血液病的临床观察

Clinical observation of hematologic malignancies patients treated by hematopoietic stem cell transplantation

目的:观察我院骨髓移植治疗恶性血液病的疗效、探讨移植相关并发症的预防及处理等问题.方法:4例行HLA相合的同胞间异基因外周干细胞移植(Allo-PBSCT)、2例行自体外周干细胞移植(APBSCT)和1例行自体骨髓移植(Auto-BMT).结果:全部病例均成功造血重建.中性粒细胞≥0.5×109/L平均时间为11天;血小板≥20×109/L平均时间为16天;发生Ⅱ～Ⅲ度aGVHD 1例,cGVHD 1例,溶血性贫血2例,间质性肺炎2例,中位随访时间18(6～42)月,全部病例现均存活.结论:骨髓移植治疗恶性血液病有较好疗效.

Objective：To observe the effect of bone marrow transplantation （BMT） in the treatment of hematologic malignancies and explore the issue about the prevention and treatment for complications correlated with BMT. Methods：4 patients were treated with allogenic peripheral blood stem cell transplantation（Allo-PBSCT） and 2 patients with autologous peripheral blood stem cell transplantation（Auto-PBSCT） and 1 patient with autologous bone marrow transplantation（Auto-BMT）. Results：all patients acquired hemopoietic reconstruction,The average time was ll day for neutrophils≥0. 5×10^6/L and 16 day for platelets≥20. 0×10^9/L. Ⅱ-Ⅲ acute graft versus host disease（aGVHD） occurred in 1 patient and chronic graft versus host disease cGVHD in 1 patient, hemolytic anemia occurred in 2 patients. Interstitial pneumonitis occurred in 2 patients. Median time of follow-up was 18 months（6-42 ）. All the patients are living now. Conclusion：BMT has good therapeutic effect on hemotologic malignancies.