芳香化酶细胞色素P450及CA_(125)联合检测对子宫内膜异位症的诊断价值

Diagnostic value of the detection of aromatase cytochrome P450 and CA_(125) for endometriosis

目的:探讨子宫内膜芳香化酶细胞色素P450(简称芳香化酶P450),CA125联合检测对子宫内膜异位症(简称内异症)的诊断价值。方法:36例经腹腔镜检或开腹手术证实为内异症的患者为研究组,22例非内异症的不孕或盆腔疼痛妇女为对照组。化学发光法测定血CA125值。术中取子宫内膜,应用免疫组织化学方法,检测芳香化酶P450在上述妇女子宫内膜的表达情况。结果:血CA125值测定用于诊断内异症的敏感性为44%,特异性为82%,阳性预测值为80%,阴性预测值为47%;子宫内膜芳香化酶用于诊断内异症的敏感性为83%,特异性为86%,阳性预测值为91%,阴性预测值为76%;免疫组织化学方法检测芳香化酶P450联合血CA125用于诊断内异症的敏感性为91.7%,特异性为68.2%。结论:子宫内膜芳香化酶及CA125联合检测对内异症诊断价值高,尤其对于早期内异症患者,明显优于血CA125值测定。

Objective To evaluate the mens for aromatase cytochrome P450 and CA diagnostic value of examining endometrial biopsy speci-25 for endometriosis. Methods The expression of aromatase cytochrome P450 in endometrium was detected by immunohistochemical analysis for 36 endometriosis women and 22 non-endometriosis but subfertility or pelvic pain women served as controls; the serum CA125 levels were measured by chemical radiation method. Results By measuring serum CA125 , the sensitivity of the serum CA125 assay was 44% , the specificity was 82% , the positive predictive value was 80% , and the negative predictive value was 47% ; the sensitivity of aromatase cytochrome P450 in biopsy endometrium of endometriosis was 82% , the specificity was 59% , the positive predictive value was 76%, and the negative predictive value was 67%. Conclusion The combination assay of aromatase cytochrome P450 in eutopic endometrium and CA125 can be used as a diagnostic test for endometriosis, especially for the early stage of endometriosis, which is superior to the assay of CA125.